Structural and functional connectivity associations with anterior cingulate sulcal variability.
Luke Harper1, Olof Strandberg1, Nicola Spotorno1
1Lund University.
Research Square
|January 23, 2024
Summary
The presence of a left paracingulate sulcus (PCS) in healthy adults is linked to altered brain structural and functional connectivity. This neurodevelopmental variation may influence cognitive function and brain networks.
Area of Science:
- Neuroimaging
- Human Brain Anatomy
- Cognitive Neuroscience
Background:
- Sulcation patterns in the anterior cingulate, specifically the paracingulate sulcus (PCS), emerge during late gestation.
- PCS presence has potential implications for cognitive function and neurological conditions.
Approach:
- Retrospective analysis of resting-state functional connectivity and diffusion-weighted tractography data.
- Examined a cohort of 129 healthy adults (<60 years old).
- Investigated the impact of ipsilateral PCS presence on brain structural and functional connectivity.
Key Points:
- Left PCS presence correlated with reduced fractional anisotropy in specific cingulum bundle segments.
- Increased radial diffusivity and tract volume in the left peri-genual region were observed with left PCS.
- Altered frontal resting-state functional connectivity was identified in individuals with a left PCS.
Conclusions:
- Novel association found between neurodevelopmental sulcation (PCS) and altered structural connectivity in healthy adults.
- Evidence supports a link between structural and functional brain connectivity influenced by PCS.
- This connection may involve highly connected local functional networks relying on short association fibers.
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