Related Experiment Video
Updated: Jul 5, 2025
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
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Obesity shapes selection for driver mutations in cancer
Cerise Tang1, Venise Jan Castillon1, Michele Waters1
1Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Medrxiv : the Preprint Server for Health Sciences
|January 23, 2024
Summary
Obesity is linked to specific tumor mutations in several cancers, including lung and endometrial types. This suggests obesity may drive cancer
Area of Science:
- Oncology
- Genomics
- Cancer Etiology
Background:
- Obesity is a known risk factor for many cancers.
- The specific relationship between obesity and cancer genomic subtypes remains unclear.
Approach:
- The study analyzed two large clinicogenomic datasets.
- Researchers investigated the association between obesity and tumor genotype.
Key Points:
- Obesity was linked to distinct driver mutations in lung adenocarcinoma.
- Specific mutations were also observed in endometrial carcinoma and cancers of unknown primary.
- These associations were independent of clinical factors and genetic ancestry.
Conclusions:
- Obesity is associated with specific tumor genomic alterations.
- Obesity may contribute to the diverse origins and subtypes of cancer.
- Findings highlight obesity as a factor in cancer's etiological heterogeneity.
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