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Updated: Jul 5, 2025
10:12
Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
Published on: January 10, 2019
18.5K
Cell and tissue-specific glycosylation pathways informed by single-cell transcriptomics
Panagiotis Chrysinas1, Shriramprasad Venkatesan1, Isaac Ang2
1Department of Chemical and Biological Engineering, University at Buffalo-SUNY, Buffalo, NY, 14260, USA.
Biorxiv : the Preprint Server for Biology
|January 23, 2024
Summary
Single human cells express about half of their potential glycogenes, with distinct hierarchies and tissue-specific patterns. Transcription factors reveal coordinated control over glycosylation processes across various organ systems.
Area of Science:
- Glycosciences
- Single-cell biology
- Human genomics
Background:
- Single-cell studies have advanced biology but are underdeveloped in Glycosciences.
- Understanding cellular glycosylation is crucial for various biological processes.
Conclusions:
- The average human cell expresses approximately half of its glycogene repertoire.
- Glycosylation patterns are cell- and tissue-specific, influenced by organ origin.
- Transcription factors play a key role in orchestrating diverse glycosylation processes.
- Webtools are provided for exploring these complex interconnections.
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