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Related Experiment Video

Updated: Jul 5, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

Cell and tissue-specific glycosylation pathways informed by single-cell transcriptomics.

Panagiotis Chrysinas¹, Shriramprasad Venkatesan¹, Isaac Ang²

¹Department of Chemical and Biological Engineering, University at Buffalo-SUNY, Buffalo, NY, 14260, USA.

Biorxiv : the Preprint Server for Biology

|January 23, 2024

Summary

This summary is machine-generated.

Single human cells express about half of their potential glycogenes, with distinct hierarchies and tissue-specific patterns. Transcription factors reveal coordinated control over glycosylation processes across various organ systems.

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Last Updated: Jul 5, 2025

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Area of Science:

Glycosciences
Single-cell biology
Human genomics

Background:

Single-cell studies have advanced biology but are underdeveloped in Glycosciences.
Understanding cellular glycosylation is crucial for various biological processes.

Conclusions:

The average human cell expresses approximately half of its glycogene repertoire.
Glycosylation patterns are cell- and tissue-specific, influenced by organ origin.
Transcription factors play a key role in orchestrating diverse glycosylation processes.
Webtools are provided for exploring these complex interconnections.