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Updated: Jul 5, 2025
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Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
Published on: November 11, 2021
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N-cadherin dynamically regulates pediatric glioma cell migration in complex environments
Dayoung Kim1, James M Olson2,3, Jonathan A Cooper1
1Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Biorxiv : the Preprint Server for Biology
|January 23, 2024
Summary
Pediatric high-grade glioma cells adapt migration by regulating N-cadherin interactions. This protein
Area of Science:
- Neuro-oncology
- Cellular Biology
- Biochemistry
Background:
- Pediatric high-grade gliomas are aggressive, invasive, and largely incurable brain tumors.
- Understanding glioma cell migration mechanisms in complex microenvironments is crucial.
- N-cadherin expression correlates with poorer survival in pediatric gliomas.
Conclusions:
- Pediatric glioma cells dynamically regulate N-cadherin and cell-cell contacts to adapt migration to diverse microenvironments.
- YAP1/TAZ signaling plays a key role in modulating N-cadherin dynamics during migration.
- Targeting N-cadherin interactions may offer novel therapeutic strategies for pediatric gliomas.
Keywords:
N-cadherinYAP1cell-cell adhesioncollective migrationendocytosisleader cellpediatric brain tumorpediatric high-grade gliomaMore Related Videos
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