Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programs
Mariia Minaeva1, Júlia Domingo2, Philipp Rentzsch1
1Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, 17165, Sweden.
Biorxiv : the Preprint Server for Biology
|January 23, 2024
Summary
Researchers created a new method to map transcription factor regulons, providing cell-specific insights into gene regulation crucial for understanding diseases like cancer.
Area of Science:
- Molecular Biology
- Genomics
- Systems Biology
Background:
- Transcription factors (TFs) are critical for cellular identity and disease pathogenesis.
- Existing data resources for cell-specific TF-to-target gene annotations are limited.
Conclusions:
- The developed method provides a valuable tool for systematic exploration of cell-specific transcriptional regulation.
- Network analysis of these regulons aids in deciphering disease mechanisms.
- The approach is broadly applicable to other cell types of interest.
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