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Updated: Jul 5, 2025
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In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
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Tapping Into the Human Spinal Locomotor Centres With Transspinal Stimulation
Andreas Skiadopoulos1, Maria Knikou1
1City University of New York and College of Staten Island.
Research Square
|January 23, 2024
Summary
Transspinal stimulation modulates human locomotion by enhancing gait symmetry and dynamic stability. This neuromodulatory strategy impacts joint kinematics and coordination, suggesting potential for clinical applications in movement disorders.
Area of Science:
- Neuroscience
- Biomechanics
- Motor Control
Background:
- Human locomotion relies on spinal neuronal networks similar to those in animals.
- Transspinal stimulation (TSS) is a technique used to modulate these networks for improving motor function in individuals with paralysis.
- The precise effects of TSS on locomotor control at varying frequencies and intensities remain largely uncharacterized.
Conclusions:
- Transspinal stimulation is an effective neuromodulatory strategy that directly influences gait symmetry and dynamic stability.
- The findings support the potential of TSS for therapeutic interventions aimed at improving locomotion.
- Further systematic investigation into optimal TSS protocols for clinical applications is warranted.
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