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Related Experiment Video

Updated: Jul 5, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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Neuro-environmental interactions: a time sensitive matter.

Azzurra Invernizzi1, Stefano Renzetti2, Elza Rechtman1

  • 1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in Computational Neuroscience
|January 23, 2024
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Summary
This summary is machine-generated.

Environmental metal exposures, including lead, chromium, and copper, significantly impact resting-state brain dynamics in adolescents. This highlights the need to account for chemical exposures when assessing brain function.

Keywords:
XGB classifierexposome analysisfMRImachine learningresting state

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Area of Science:

  • Neuroscience
  • Environmental Health
  • Toxicology

Background:

  • Resting-state (rs) neurophysiological dynamics assessment requires controlling environmental factors.
  • Temporally-distal environmental inputs, such as metal exposures, may confound rs functional magnetic resonance imaging (rs-fMRI) findings.

Purpose of the Study:

  • To investigate the impact of past metal exposures on functional brain dynamics measured by rs-fMRI.
  • To develop a predictive model for rs dynamics using metal exposure biomarkers.

Main Methods:

  • An interpretable XGBoost-shapley additive explanation (SHAP) model was used.
  • 124 adolescents (ages 13-25) from the PHIME study provided biological samples (saliva, hair, nails, blood, urine) for metal analysis (manganese, lead, chromium, copper, nickel, zinc).
  • Resting-state fMRI scans were acquired, and global efficiency (GE) was computed using graph theory metrics.

Main Results:

  • The predictive model significantly correlated measured and predicted GE (p < 0.001, r = 0.36).
  • Lead, chromium, and copper were the most important predictors of GE.
  • Approximately 13% of the variability in GE was explained by metal exposures.

Conclusions:

  • A significant portion of resting-state brain dynamics is influenced by recent metal exposures.
  • It is crucial to consider and control for past and current chemical exposures in rs-fMRI studies.
  • Findings underscore the link between environmental toxicology and neurophysiology.