Rosacea, microbiome and probiotics: the gut-skin axis

Area of Science:

• Dermatology and Microbiology
• Investigates the complex interplay between the gut microbiome, skin microbiome, and inflammatory skin diseases.

Background:

• Rosacea is a chronic inflammatory skin condition impacting quality of life and mental health.
• Pathophysiology involves immune dysregulation, vascular/nervous alterations, and microbial triggers.
• The gut-skin axis, a bidirectional communication pathway, is implicated in inflammatory skin diseases.

Purpose of the Study:

• To review current knowledge on the microbiome's role in rosacea pathogenesis.
• To explore the impact of the gut-skin axis in rosacea patients.
• To assess the potential of microbiota modulation, including probiotics, for rosacea treatment.

Main Methods:

• Literature review synthesizing existing research on rosacea, microbiome, and gut-skin axis.
• Analysis of next-generation sequencing data and its implications for understanding microbial communities.
• Examination of therapeutic strategies targeting microbial modulation.

Main Results:

• The gut-skin axis in rosacea is underexplored compared to other inflammatory skin diseases.
• Microbiome characterization in rosacea patients requires further investigation.
• Probiotic supplementation shows potential therapeutic benefits, mirroring outcomes in other conditions.

Conclusions:

• Understanding the microbiome's influence on rosacea pathogenesis is crucial.
• Targeting skin and gut microbiota modulation presents a promising avenue for improving rosacea clinical outcomes.
• Further research is needed to elucidate specific mechanisms and optimize therapeutic interventions.