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Prinzmetal's angina during 5-fluorouracil chemotherapy
The American Journal of Medicine
|March 1, 1987
Summary
Intravenous 5-fluorouracil therapy can cause variant angina due to coronary vasospasm. Calcium antagonist therapy, including nifedipine and diltiazem, effectively prevented this adverse event in a patient case study.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- 5-fluorouracil (5-FU) is a common chemotherapy agent.
- Angina pectoris is chest pain caused by reduced blood flow to the heart.
- Variant angina, or Prinzmetal's angina, involves coronary artery vasospasm.