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Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Integrative analysis of circRNA networks in postoperative cognitive dysfunction
Jian Tang1, Yanhong Tang1, Peimin Lin1
1Department of Anesthesiology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, P. R. China.
The International Journal of Neuroscience
|January 23, 2024
Summary
This study identifies key circular RNAs (circRNAs) and genes involved in Postoperative Cognitive Dysfunction (POCD). These findings illuminate potential molecular targets for understanding and treating POCD.
Area of Science:
- Molecular Biology
- Genomics
- Neuroscience
Background:
- Postoperative Cognitive Dysfunction (POCD) is a complex neurological condition.
- Understanding the molecular mechanisms underlying POCD is crucial for developing effective interventions.
Purpose of the Study:
- To investigate the role of circular RNAs (circRNAs) in the molecular pathology of POCD.
- To identify regulatory networks and potential therapeutic targets associated with POCD.
Main Methods:
- Analysis of the Gene Expression Omnibus Series (GSE) 147277 dataset.
- Construction of competing endogenous RNA (ceRNA) and Protein-Protein Interaction (PPI) networks.
Main Results:
- Identified 10 differentially expressed circRNAs associated with POCD.
- Constructed a ceRNA network involving hsa_circ_0003424 and hsa-miR-193b-5p.
- Highlighted 10 core hub genes in the PPI network, including PTEN and STAT3.
Conclusions:
- circRNAs play a significant role in the molecular landscape of POCD.
- The identified circRNAs, ceRNA network, and hub genes (PTEN, STAT3) represent potential therapeutic targets for POCD.
