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Tocolysis with oral magnesium.

R W Martin, D K Gaddy, J N Martin

    American Journal of Obstetrics and Gynecology
    |February 1, 1987
    PubMed
    Summary
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    Oral magnesium gluconate effectively increased serum magnesium levels in patients receiving tocolysis. This study shows oral magnesium can significantly raise magnesium levels, aiding continued treatment.

    Area of Science:

    • Obstetrics and Gynecology
    • Pharmacology
    • Clinical Chemistry

    Background:

    • Parenteral magnesium sulfate is used for tocolysis to manage preterm labor.
    • Maintaining adequate serum magnesium levels is crucial for effective tocolysis.
    • Oral magnesium supplementation may offer a convenient alternative for long-term management.

    Purpose of the Study:

    • To evaluate the efficacy of oral magnesium gluconate in maintaining serum magnesium levels for tocolysis.
    • To assess the pharmacokinetic profile of orally administered magnesium gluconate in this patient population.

    Main Methods:

    • Seventeen patients receiving parenteral magnesium sulfate for tocolysis were switched to oral magnesium gluconate.
    • Serum magnesium levels were measured before and 2 hours after initiating oral magnesium therapy.

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  • Patient tolerance and side effects were monitored.

    • Main Results:

    • Oral magnesium gluconate significantly increased mean serum magnesium levels from 1.44 +/- 0.22 mg/100 ml to 2.16 +/- 0.32 mg/100 ml (p < 0.05).
    • The treatment was generally well-tolerated, with only one patient experiencing mild nausea.

    Conclusions:

    • Oral magnesium gluconate is effective in raising serum magnesium levels significantly.
    • This suggests oral magnesium gluconate can be a viable option for continued tocolysis, potentially improving patient convenience and long-term management.