Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

573
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
573
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

452
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
452

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial aqueous suppressant therapy after glaucoma drainage device implantation: a systematic review.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Deep learning in glaucoma referral: Performance assessment using a real-world setting.

Acta ophthalmologica·2026
Same author

Update on the structure-function relationship in glaucoma.

Survey of ophthalmology·2026
Same author

Glaucoma drainage devices as a novel treatment option in the management of recurrent iris cysts.

European journal of ophthalmology·2026
Same author

Outcomes of Ab Interno 63 µm vs. 45 µm XEN<sup>®</sup> Gel Stent in Open-Angle Glaucoma: A Five-Year Follow-Up Study.

Journal of clinical medicine·2026
Same author

Efficacy and Safety of Preservative-Free Bimatoprost 0.01% Gel in Patients with Open-Angle Glaucoma and Ocular Hypertension: Results from Two Phase III Randomized Trials.

Clinical ophthalmology (Auckland, N.Z.)·2026

Related Experiment Video

Updated: Jul 5, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.4K

Differentiating Ischemic Optic Neuropathy from Glaucoma Using Diagnostic Tests.

Frédéric Smeets1, Astrid Margot2, João Barbosa-Breda2,3,4

  • 1Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Ophthalmic Research
|January 23, 2024
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) helps differentiate glaucoma from anterior ischemic optic neuropathy (AION). Key differences are found in optic nerve head parameters, retinal nerve fiber layer (RNFL) thinning patterns, and macular vascularity.

Keywords:
Anterior ischemic optic neuropathyGlaucomaOptical coherence tomographyOptical coherence tomography angiography

More Related Videos

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
08:57

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

4.0K
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.4K
Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
08:57

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

4.0K
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

14.1K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Neurology

Background:

  • Anterior ischemic optic neuropathy (AION) can be misdiagnosed as glaucoma, complicating differential diagnosis.
  • Accurate diagnosis is crucial for appropriate patient management and treatment strategies.

Purpose of the Study:

  • To summarize diagnostic test differences aiding in the correct diagnosis of glaucoma versus AION.
  • To highlight the utility of optical coherence tomography (OCT) in distinguishing these conditions.

Main Methods:

  • A systematic literature search was conducted across four databases (MEDLINE, Embase, Web of Science, Cochrane) following PRISMA 2009 guidelines.
  • 39 English-language studies published within the last 20 years were included after screening 772 references.

Main Results:

  • Optical coherence tomography (OCT) was utilized in 90% of included studies.
  • Glaucomatous eyes showed distinct optic nerve head parameters (e.g., greater cup area, lower rim volume) and retinal nerve fiber layer (RNFL) thinning in specific sectors (superotemporal, inferotemporal, inferonasal) compared to AION eyes (superonasal thinning).
  • OCT angiography revealed reduced macular vessel density in glaucoma, while parapapillary choroidal vascularity was preserved in AION.

Conclusions:

  • Optic nerve head parameters derived from OCT imaging are most informative for differentiating glaucoma and AION.
  • Distinct patterns of RNFL thickness loss and differences in macular structure and vascularity aid in differential diagnosis.