Ten-year experience of whole lung lavage in pediatric Pulmonary Alveolar Proteinosis
Related Experiment Video
Updated: Jul 5, 2025
A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
Published on: December 15, 2014
Katja Nickel1, Katharina Schütz2, Julia Carlens2
1Clinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Background:
Pulmonary Alveolar Proteinosis (PAP) is extremely rare and can be caused by hereditary dysfunction of the granulocyte macrophage colony-stimulating factor receptor (GM-CSF) receptor, autoantibodies against GM-CSF, or other diseases leading to alveolar macrophage (AM) dysfunction. This leads to protein accumulation in the lung and severe dyspnea and hypoxemia. Whole lung lavage (WLL) is the first line treatment strategy.
Methods:
Here, we present data from more than ten years of WLL practice in pediatric PAP. WLL performed by the use of a single lumen or double lumen tube (SLT vs. DLT) were compared for technical features, procedure time, and adverse events.
Results:
A total of n=57 procedures in six PAP patients between 3.5 and 14.3 years of age were performed. SLT based WLL in smaller children was associated with comparable rates of adverse events but with longer intervention times and postprocedural intensive care treatment when compared to DLT based procedures.
Discussion:
Our data shows that WLL is feasible even in small children. DLT based WLL seems to be more effective, and our data supports the notion that it should be considered as early as possible in pediatric PAP.
Conclusion:
WLL lavage is possible in small PAP patients but should performed in close interdisciplinary cooperation and with age appropriate protocols.
