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Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients

Li Sun1, Dongliang Zhang2, Jiawen Liu1

  • 1Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Renal Failure
|January 24, 2024
PubMed

Insights

Left ventricular remodeling partially improved one year after kidney transplant, with changes linked to mineral and bone disorder. Key factors influencing these cardiac changes were identified.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Mineral and bone disorder (MBD) and its impact on cardiac remodeling in kidney transplant recipients (KTRs) remain understudied.
  • Kidney transplantation (KT) significantly alters systemic metabolism, potentially affecting cardiovascular health.
  • Systematic evaluation of LV remodeling post-KT and its association with MBD is needed.

Purpose of the Study:

  • To assess changes in left ventricular (LV) remodeling one year after kidney transplantation (KT).
  • To identify factors influencing LV remodeling in KTRs, particularly those related to MBD.
  • To explore the relationship between MBD and LV remodeling post-KT.

Main Methods:

  • Prospective follow-up of 95 KTRs before and one year after KT.
  • Assessment of traditional risk factors and bone metabolism indicators.
  • Echocardiographic measurement of LV mass index (LVMI), ejection fraction (LVEF), and diastolic dysfunction (LVDD).

Main Results:

  • One year post-KT, MBD markers showed partial improvement, alongside decreased LVMI, left ventricular hypertrophy (LVH), and LVDD, and increased LVEF.
  • LVH correlated with postoperative intact parathyroid hormone (iPTH) levels.
  • Factors like age, BMI, diabetes, dialysis duration, and lipid profiles were associated with LV remodeling.

Conclusions:

  • Left ventricular remodeling demonstrates partial improvement following kidney transplantation.
  • The observed cardiac remodeling changes are closely associated with the status of mineral and bone disorder.
Abstract

Keywords:
Kidney transplantationleft ventricular hypertrophyleft ventricular remodelingmineral and bone disorder

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