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Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Related Experiment Video

Updated: Jul 5, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Left Atrial Strain Predicts Cardiovascular and All-Cause Mortality.

Chien-Wei Chang1,2, Wen-Hsien Lee2,3,4, Tien-Chi Huang2

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University.

Acta Cardiologica Sinica
|January 24, 2024
PubMed
Summary
This summary is machine-generated.

Left atrial strain predicts mortality in patients, even those with borderline diastolic function. This study confirms its value as a survival predictor with extended follow-up.

Keywords:
Cardiovascular mortalityLeft atrial strainOverall mortality

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Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Function Assessment

Background:

  • Left atrial strain is a key indicator of left atrial function.
  • Previous studies had limited follow-up periods and did not focus on patients with borderline diastolic function.
  • This study aimed to assess left atrial strain's predictive value for mortality with a longer follow-up.

Purpose of the Study:

  • To investigate the survival predictive value of left atrial strain using a longer follow-up duration.
  • To evaluate the prognostic capability of left atrial strain in patients with borderline diastolic function.

Main Methods:

  • 652 participants underwent 2-D speckle tracking echocardiography to assess left atrial reservoir function (peak atrial longitudinal strain).
  • Study endpoints included all-cause and cardiovascular mortality.
  • Median follow-up was 92 months.

Main Results:

  • Lower left atrial strain was a significant predictor of both all-cause and cardiovascular mortality in univariable analysis.
  • After adjusting for clinical and echocardiographic parameters, lower left atrial strain remained associated with increased all-cause (HR=0.942) and cardiovascular mortality (HR=0.915).
  • Left atrial strain also predicted cardiovascular mortality in patients with borderline left ventricular diastolic function.

Conclusions:

  • Left atrial strain is a valuable predictor of all-cause and cardiovascular mortality.
  • Its predictive value persists even after adjusting for common clinical and echocardiographic factors.
  • Left atrial strain is a significant prognostic marker, particularly in patients with borderline diastolic function.