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Updated: Jul 5, 2025
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Association of multiple sclerosis with stroke: A comprehensive review
Mohammed Dheyaa Marsool Marsool1, Priyadarshi Prajjwal2, Jobby John3
1Al-kindy College of Medicine University of Baghdad Baghdad Iraq.
Background:
Multiple sclerosis (MS) is a chronic immune-mediated disorder characterized by the degradation of the myelin sheath in the central nervous system. Research indicates that individuals with MS exhibit a higher susceptibility to stroke compared to the general population. This association is rooted in shared underlying mechanisms, specifically involving neuroinflammatory processes.
Methodology:
We performed an extensive search on PubMed, MEDLINE, Embase, Scopus, and Google Scholar using specific terms. The search terms included variations of "multiple sclerosis," "stroke," "cerebrovascular disease," "vascular risk factors," "disease-modifying therapies," and "neuroinflammation." The search was limited to articles published from January 1, 2000, up to 31 May, 2023.
Results And Discussion:
Stroke, a global health burden characterized by significant mortality and adult disability, underscores the critical importance of understanding the link between MS and stroke. Despite a growing body of research establishing an elevated risk of stroke in MS patients, notable information gaps persist. Limited prospective multicenter studies on stroke incidence in MS patients contribute to an incomplete understanding of the precise relationship between these two conditions.
Conclusion:
In conclusion, this review underscores the critical need for a thorough understanding of the complex relationship between MS and stroke. The identified risk factors and the influence of MS DMTs on stroke risk necessitate further investigation to inform evidence-based preventive and therapeutic strategies. Bridging the existing information gaps through prospective multicenter studies is imperative for a comprehensive understanding of this association. The development of targeted diagnostic and therapeutic approaches for acute stroke risk in MS patients is paramount to mitigate the impact of these debilitating conditions. Ultimately, this review serves as a foundation for future efforts to enhance preventative measures and therapeutic interventions, thereby improving the overall quality of life for individuals with MS susceptible to strokes.
Insights
Individuals with multiple sclerosis (MS) have an increased stroke risk due to shared neuroinflammatory pathways. Further research is needed to understand risk factors and treatments for stroke in MS patients.
Area of Science:
- Neuroimmunology
- Neurology
- Vascular Neurology
Background:
- Multiple sclerosis (MS) is a chronic immune-mediated central nervous system disorder.
- MS patients show increased susceptibility to stroke, linked to shared neuroinflammatory mechanisms.
Purpose of the Study:
- To review the current understanding of the association between multiple sclerosis and stroke.
- To identify knowledge gaps and inform future research directions.
Main Methods:
- Extensive literature search across PubMed, MEDLINE, Embase, Scopus, and Google Scholar.
- Search terms included variations of "multiple sclerosis," "stroke," "vascular risk factors," and "neuroinflammation."
- Articles published between January 1, 2000, and May 31, 2023, were included.
Main Results:
- Stroke is a significant cause of mortality and disability, with a recognized elevated risk in MS patients.
- Existing research highlights an increased stroke risk in MS, but significant information gaps remain.
- Limited prospective multicenter studies hinder a complete understanding of the MS-stroke relationship.
Conclusions:
- A comprehensive understanding of the MS-stroke relationship is crucial.
- Further investigation into risk factors and the impact of MS disease-modifying therapies (DMTs) on stroke risk is necessary.
- Prospective studies and targeted interventions are vital to improve outcomes for MS patients at risk of stroke.
