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Association of multiple sclerosis with stroke: A comprehensive review
Mohammed Dheyaa Marsool Marsool1, Priyadarshi Prajjwal2, Jobby John3
1Al-kindy College of Medicine University of Baghdad Baghdad Iraq.
Health Science Reports
|January 24, 2024
Summary
Individuals with multiple sclerosis (MS) have an increased stroke risk due to shared neuroinflammatory pathways. Further research is needed to understand risk factors and treatments for stroke in MS patients.
Area of Science:
- Neuroimmunology
- Neurology
- Vascular Neurology
Background:
- Multiple sclerosis (MS) is a chronic immune-mediated central nervous system disorder.
- MS patients show increased susceptibility to stroke, linked to shared neuroinflammatory mechanisms.
Purpose of the Study:
- To review the current understanding of the association between multiple sclerosis and stroke.
- To identify knowledge gaps and inform future research directions.
Main Methods:
- Extensive literature search across PubMed, MEDLINE, Embase, Scopus, and Google Scholar.
- Search terms included variations of "multiple sclerosis," "stroke," "vascular risk factors," and "neuroinflammation."
- Articles published between January 1, 2000, and May 31, 2023, were included.
Main Results:
- Stroke is a significant cause of mortality and disability, with a recognized elevated risk in MS patients.
- Existing research highlights an increased stroke risk in MS, but significant information gaps remain.
- Limited prospective multicenter studies hinder a complete understanding of the MS-stroke relationship.
Conclusions:
- A comprehensive understanding of the MS-stroke relationship is crucial.
- Further investigation into risk factors and the impact of MS disease-modifying therapies (DMTs) on stroke risk is necessary.
- Prospective studies and targeted interventions are vital to improve outcomes for MS patients at risk of stroke.
