Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

3.8K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
3.8K
Necrosis01:16

Necrosis

4.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The effect of chelerythrine on the hypertrophy of cardiac myocytes of neonatal rats induced by different glucose levels and its mechanism].

Yao xue xue bao = Acta pharmaceutica Sinica·2009
Same author

Overexpression of Midkine promotes the viability of BA/F3 cells.

Biochemical and biophysical research communications·2009
Same author

Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation.

Brain research·2009
Same author

[Open-path online monitoring of ambient atmospheric CO2 based on laser absorption spectrum].

Guang pu xue yu guang pu fen xi = Guang pu·2009
Same author

[Effects of Sarcandra glabra extract on immune activity in restraint stress mice].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2009
Same author

No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population.

Neuroscience letters·2009

Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

1.9K

Nanomaterial-induced pyroptosis: a cell type-specific perspective.

Zhiyong Wang1, Min Wang2, Xuan Zeng3

  • 1Department of Immunology, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.

Frontiers in Cell and Developmental Biology
|January 24, 2024
PubMed
Summary
This summary is machine-generated.

This review explores how nanomaterials (NMs) trigger pyroptosis, a cell death process. Understanding NM-induced pyroptosis in various cells is key for developing safer nanomedicine.

Keywords:
nanomaterialsnon-tumor cellspyroptosistherapeutic applicationstoxicology

More Related Videos

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.7K
Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
05:14

Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells

Published on: May 31, 2024

1.2K

Related Experiment Videos

Last Updated: Jul 5, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
06:12

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

1.9K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.7K
Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
05:14

Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells

Published on: May 31, 2024

1.2K

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Toxicology

Background:

  • Pyroptosis is a crucial inflammatory cell death pathway.
  • Nanomaterials (NMs) are increasingly used in medicine, necessitating understanding their biological effects.
  • The interaction between NMs and cellular death pathways like pyroptosis is complex and requires further investigation.

Purpose of the Study:

  • To review advancements in nanomaterial-induced pyroptosis.
  • To elucidate the mechanisms and classifications of pyroptosis.
  • To highlight the role of NMs in modulating cell death pathways in non-tumorous cells.

Main Methods:

  • Retrospective analysis of existing literature on NM-induced pyroptosis.
  • Examination of pyroptosis mechanisms and classifications.
  • Review of studies on NMs in various non-tumorous cellular environments.

Main Results:

  • Nanomaterials can induce pyroptosis through diverse mechanisms.
  • NMs demonstrate multifunctionality in modulating cell death pathways.
  • Current research has identified key knowledge gaps in NM-NM-induced pyroptosis.

Conclusions:

  • Further research is needed on NM-triggered pyroptosis in non-tumor-specific cells.
  • Investigating the interplay between biological/environmental factors and NM-cell interactions is crucial.
  • Understanding these interactions will aid in developing safer nanomedical therapeutics.