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eGFR slope as a primary endpoint for clinical trials of CKD progression: one size fits all?

Balazs Odler1, Edouard L Fu2

  • 1Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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|January 24, 2024
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Abstract

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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