Guizhi longgu muli decoction ameliorates pathological changes in heart and bone in ovariectomized rats

The aim of this study is to investigate the pathological changes in cardiac function, blood pressure, blood lipids and bone metabolism in ovariectomized (OVX) rats, as well as the intervention effect of Guizhi Longgu Muli decoction (GZLM). Bilateral oophorectomy was used to establish an OVX menopausal model. Four groups of rats were randomly selected: Sham surgery group, OVX group, estradiol (0.018g/L) and GZLM group (20g/kg). Cardiac function was assessed using ultrasound, blood pressure was measured using the tail cuff method. The oxidase method was used to determine the total cholesterol (TC) and triglycerides in serum. Direct measurement of high-density lipoprotein and low-density lipoprotein levels (LDL-C). Hematoxylin eosin staining and electron microscopy examination of myocardial structure. Microscopic CT was used to determine the bone microstructure. GZLM improved pathological cardiac changes and reduced the LVIDs, LVVols and LVVold. There was a decrease in systolic pressure, diastolic pressure and mean blood pressure in GZLM group. A decrease in serum TC and LDL-C levels was observed in the GZLM group. The BMD, BV/TV, Tb.Th, Tb.N of GZLM group raised, while Tb.SP and SMI significantly decreased or decreased. GZLM may have the effect of improving abnormal cardiac structure and function, promoting bone metabolism in OVX rats.