Related Experiment Video
Updated: Jul 14, 2026
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Neoadjuvant endocrine treatment in hormone receptor-positive breast cancer: Does it result in more breast-conserving
Merel E van de Loo1, Layla Andour1, Anne E van Heesewijk1
1Department of Surgery, Medical Center Haaglanden, The Hague, The Netherlands.
Background:
Patients with locally advanced endocrine positive tumors who will not benefit from chemotherapy can be treated by either primary surgery or neoadjuvant endocrine therapy (NET). How often does NET result in breast-conserving surgery (BCS)?
Methods:
We conducted a literature search in PubMed and Embase, to identify articles on surgical treatment after NET.
Results:
In 19 studies the pathological complete response (pCR) rate was reported after NET; an overall pCR rate of 1% was found. Compared with neoadjuvant chemotherapy (NCT), the BCS rate was significantly higher after NET (OR 0.60; 95% CI, 0.51-0.69; P < 0.00001). The surgical conversion rate was reported in eight studies [4-75.9%], with a mean of 30.2%.
Conclusion:
This review found that one out of three patients becomes eligible for BCS after treatment with NET.
More Related Videos
13:35Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
09:11Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
