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Related Concept Videos

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Fracture Risk Among Living Kidney Donors 25 Years After Donation.

Hilal Maradit Kremers1,2, Brandon R Grossardt3, Adam R Miller4

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Living kidney donors had fewer overall fractures but more vertebral fractures than matched controls. Vitamin D3 supplementation may help reduce vertebral fractures and associated morbidity in these individuals.

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Area of Science:

  • Nephrology
  • Orthopedics
  • Public Health

Background:

  • Living kidney donors may face increased fracture risks due to physiological changes post-donation.
  • These changes include reduced kidney mass, lower serum 1,25-dihydroxyvitamin D, and elevated parathyroid hormone levels.

Purpose of the Study:

  • To compare the incidence of overall and site-specific fractures in living kidney donors versus carefully matched controls.
  • To identify potential long-term bone health implications of living kidney donation.

Main Methods:

  • A survey study involving 2132 living kidney donors and 2014 population-based nondonor controls.
  • Participants completed surveys on bone health and fracture history.
  • Standardized incidence ratios (SIRs) were used to compare fracture rates.

Main Results:

  • Living kidney donors exhibited a significantly lower overall fracture rate (SIR, 0.89) compared to controls.
  • However, living kidney donors had a significantly higher rate of vertebral fractures (SIR, 1.42).
  • The mean follow-up time was approximately 25 years post-donation or index date.

Conclusions:

  • Living kidney donation is associated with a reduced overall fracture risk but an increased risk of vertebral fractures.
  • Interventions like vitamin D3 supplementation could potentially mitigate vertebral fracture incidence and patient morbidity.