Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

62
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
62
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

507
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
507
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

73
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
73
Receiver Operating Characteristic Plot01:15

Receiver Operating Characteristic Plot

179
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
179
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

128
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
128
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitigating Negative Transfer via Reducing Environmental Disagreement.

IEEE transactions on pattern analysis and machine intelligence·2026
Same author

Evaluation of Traumatic Subdural Hematoma Volume by Using Image Segmentation Assessment Based on Deep Learning.

Computational and mathematical methods in medicine·2022
Same author

Lsr2 of Mycobacterium tuberculosis is a DNA-bridging protein.

Nucleic acids research·2008
Same author

Amphetamine selectively enhances avoidance responding to a less salient stimulus in rats.

Journal of neural transmission (Vienna, Austria : 1996)·2008
Same author

Retrospective analysis of anterior correction and fusion for adolescent idiopathic thoracolumbar/lumbar scoliosis: the relationship between preserving mobile segments and trunk balance.

International orthopaedics·2008
Same author

Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells.

Journal of the American Society of Nephrology : JASN·2008
Same journal

Benchmarking the Robustness of Autonomous Driving to Environmental Illusions: A Lane Perception Perspective.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

Learning Topology-Aware Representations via Test-Time Adaptation for Anomaly Segmentation.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

TraGraph-GS: Trajectory Graph-based Gaussian Splatting for Arbitrary Large-Scale Scene Rendering.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

SWIFT: A Small-World Interaction Framework for Flow-Aware Trajectory Prediction in Autonomous Driving.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

HardFlow: Hard-Constrained Sampling for Flow-Matching Models Via Trajectory Optimization.

IEEE transactions on pattern analysis and machine intelligence·2026
Same journal

Industrial Brain: Self-Evolving Neuro-Symbolic Autonomy with Causal Resilience for Cyber-Physical Systems.

IEEE transactions on pattern analysis and machine intelligence·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images
08:20

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

1.5K

Weakly Supervised AUC Optimization: A Unified Partial AUC Approach.

Zheng Xie, Yu Liu, Hao-Yuan He

    IEEE Transactions on Pattern Analysis and Machine Intelligence
    |January 24, 2024
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces WSAUC, a framework for optimizing Area Under the Curve (AUC) with weak supervision. It uses reversed partial AUC (rpAUC) to effectively handle inaccurate labels in machine learning tasks.

    More Related Videos

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
    07:35

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

    Published on: October 11, 2018

    7.5K
    A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
    12:18

    A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

    Published on: January 11, 2020

    7.5K

    Related Experiment Videos

    Last Updated: Jul 5, 2025

    Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images
    08:20

    Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

    Published on: October 27, 2023

    1.5K
    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
    07:35

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

    Published on: October 11, 2018

    7.5K
    A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
    12:18

    A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

    Published on: January 11, 2020

    7.5K

    Area of Science:

    • Machine Learning
    • Data Science
    • Computer Science

    Background:

    • Real-world machine learning often faces imperfect data, known as weak supervision, including noisy, incomplete, or inexact labels.
    • Traditional methods struggle with these data imperfections, hindering reliable performance evaluation and optimization.

    Purpose of the Study:

    • To develop a unified framework, WSAUC, for addressing Area Under the Curve (AUC) optimization under various weak supervision scenarios.
    • To provide a robust and consistent approach for AUC maximization despite data contamination.

    Main Methods:

    • Framing AUC optimization in diverse weak supervision settings as minimizing AUC risk on contaminated datasets.
    • Introducing reversed partial AUC (rpAUC) as a novel, robust training objective for AUC maximization.
    • Developing the WSAUC framework to maximize empirical rpAUC for universal applicability.

    Main Results:

    • Demonstrated consistency between empirical risk minimization and true AUC under weak supervision.
    • Empirical validation of WSAUC's effectiveness across noisy label, positive-unlabeled, multi-instance, and semi-supervised learning.
    • Theoretical and experimental evidence supporting WSAUC's performance on multiple weakly supervised AUC optimization tasks.

    Conclusions:

    • WSAUC provides a universal and effective solution for AUC optimization in the presence of weak supervision.
    • The proposed rpAUC metric offers a robust objective for training models with contaminated labels.
    • The framework successfully integrates various weak supervision scenarios under a common AUC optimization approach.