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Related Experiment Videos

Evoked potentials following diazepam or fentanyl.

B L Loughnan, P S Sebel, D Thomas

    Anaesthesia
    |February 1, 1987
    PubMed
    Summary

    Fentanyl and diazepam did not significantly alter evoked potentials in patients undergoing surgery. This suggests their suitability for anesthesia when monitoring evoked responses during surgery is crucial.

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    Area of Science:

    • Anesthesiology
    • Neurophysiology

    Background:

    • Evoked potentials (EPs) are crucial for monitoring neurological function during surgery.
    • Anesthetic agents can affect EP parameters, potentially interfering with monitoring.
    • Understanding the impact of specific drugs like fentanyl and diazepam on EPs is vital.

    Purpose of the Study:

    • To investigate the effects of fentanyl and diazepam on somatosensory, visual, and brainstem auditory evoked potentials.
    • To determine if these commonly used anesthetic agents interfere with intraoperative EP monitoring.

    Main Methods:

    • 13 healthy patients undergoing elective surgery were studied.
    • Baseline evoked potentials (EPs) were recorded.
    • Either fentanyl (200 mcg IV) or diazepam (20 mg IV) was administered.
    • EPs were re-recorded within one hour post-administration.

    Main Results:

    • No significant changes in latency or amplitude were observed for somatosensory, visual, or brainstem auditory EPs.
    • Unlike some other anesthetics, fentanyl and diazepam alone did not cause dose-dependent EP alterations.
    • The findings indicate minimal impact on EP monitoring when these drugs are used individually.

    Conclusions:

    • Fentanyl and diazepam, when administered alone, do not significantly affect key EP parameters.
    • These drugs may be suitable for anesthetic techniques requiring intraoperative EP monitoring for ischemia assessment.
    • Further research could explore combined effects or different monitoring modalities.

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