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Updated: Jul 5, 2025

Localization of the Locus Coeruleus in the Mouse Brain
Published on: March 7, 2019
The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved
Lukas M Weber1, Heena R Divecha2, Matthew N Tran2
1Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Abstract:
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memory. The LC-NE system is also implicated in multiple neurological and neuropsychiatric disorders. Importantly, LC-NE neurons are highly sensitive to degeneration in both Alzheimer's and Parkinson's disease. Despite the clinical importance of the brain region and the prominent role of LC-NE neurons in a variety of brain and behavioral functions, a detailed molecular characterization of the LC is lacking. Here, we used a combination of spatially-resolved transcriptomics and single-nucleus RNA-sequencing to characterize the molecular landscape of the LC region and the transcriptomic profile of LC-NE neurons in the human brain. We provide a freely accessible resource of these data in web-accessible and downloadable formats.
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