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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

573
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
573
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

452
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
452
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

500
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
500
Computed Tomography01:10

Computed Tomography

4.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Related Experiment Video

Updated: Jul 5, 2025

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

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Published on: September 18, 2012

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Optical coherence tomography angiography in glaucoma.

Jimmy Hong1, Shayne S Tan1, Jacqueline Chua1

  • 1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Clinical & Experimental Optometry
|January 24, 2024
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography angiography (OCTA) reliably differentiates glaucoma from healthy eyes and aids monitoring in advanced cases. This technology complements traditional methods, offering valuable insights for glaucoma detection and management.

Keywords:
Angiographyglaucomaoptical coherence tomography

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma, a leading cause of irreversible blindness, is traditionally diagnosed using structural and functional metrics.
  • Optical coherence tomography angiography (OCTA) is emerging as a promising tool for glaucoma assessment.
  • Traditional methods may have limitations, especially in advanced glaucoma cases.

Purpose of the Study:

  • To review the application of OCTA in the diagnosis, monitoring, and management of glaucoma patients.
  • To evaluate OCTA's reliability, repeatability, and discriminatory power in glaucoma.
  • To explore OCTA's role in complementing existing glaucoma assessment techniques.

Main Methods:

  • A comprehensive literature search was conducted across Embase, PubMed, and Cochrane Central Register of Controlled Trials up to August 15, 2023.
  • Included were 272 original English-language studies on OCTA use in human glaucoma patients.
  • Exclusion criteria focused on non-human studies, reviews, and abstracts.

Main Results:

  • OCTA demonstrates good repeatability and reproducibility.
  • OCTA metrics effectively differentiate glaucomatous from healthy eyes and correlate with structural changes and visual field defects.
  • OCTA extends monitoring capabilities for advanced glaucoma, overcoming the 'floor effect' of traditional methods.

Conclusions:

  • OCTA is a valuable addition to traditional glaucoma assessment, particularly in complex cases.
  • Factors like OCTA machine choice, algorithms, and patient conditions can influence results; quality evaluation is crucial.
  • Further research and clinical validation are needed for routine OCTA integration in glaucoma management.