Lack of effect of compound 48/80 on human umbilical vein endothelium

Human umbilical veins have been treated with compound 48/80, a histamine liberator factor, in order to obtain information about the histamine content in the Weibel-Palade bodies. Ultrastructural observations show a lack of effect in the morphology of this organelle. Our findings suggest that the Weibel-Palade bodies are not histamine storage organelles in human umbilical vein.