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Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000-2022
Lijie Zhang1,2, Qiuru Yao1,3, Jinjing Hu1,2
1Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Background:
Alzheimer's disease is one common type of dementia. Numerous studies have suggested a correlation between Alzheimer's disease and inflammation. Microglia mainly participate in the inflammatory response in the brain. Currently, ample evidence has shown that microglia are closely related to the occurrence and development of Alzheimer's disease.
Objective:
We opted for bibliometric analysis to comprehensively summarize the advancements in the study of microglia in Alzheimer's disease, aiming to provide researchers with current trends and future research directions.
Methods:
All articles and reviews pertaining to microglia in Alzheimer's disease from 2000 to 2022 were downloaded through Web of Science Core Collection. The results were subjected to bibliometric analysis using VOSviewer 1.6.18 and CiteSpace 6.1 R2.
Results:
Overall, 7449 publications were included. The number of publications was increasing yearly. The United States has published the most publications. Harvard Medical School has published the most papers of all institutions. Journal of Alzheimer's Disease and Journal of Neuroscience were the journals with the most studies and the most commonly cited, respectively. Mt Heneka is the author with the highest productivity and co-citation. After analysis, the most common keywords are neuroinflammation, amyloid-beta, inflammation, neurodegeneration. Gut microbiota, extracellular vesicle, dysfunction and meta-analysis are the hotspots of research at the present stage and are likely to continue.
Conclusion:
NLRP3 inflammasome, TREM2, gut microbiota, mitochondrial dysfunction, exosomes are research hotspots. The relationship between microglia-mediated neuroinflammation and Alzheimer's disease have been the focus of current research and the development trend of future research.
Insights
This bibliometric analysis reveals key trends in Alzheimer's disease research, highlighting microglia's role in neuroinflammation and identifying gut microbiota and mitochondrial dysfunction as emerging hotspots.
Area of Science:
- Neuroscience
- Immunology
- Biomedical Research
Background:
- Alzheimer's disease (AD) is a prevalent form of dementia strongly linked to neuroinflammation.
- Microglia, the brain's primary immune cells, play a critical role in AD pathogenesis.
- Existing evidence underscores the intricate relationship between microglia and the development of Alzheimer's disease.
Purpose of the Study:
- To conduct a bibliometric analysis of research on microglia in Alzheimer's disease.
- To summarize advancements and identify current trends and future research directions in this field.
Main Methods:
- Bibliometric analysis of 7,449 publications from 2000-2022.
- Data sourced from Web of Science Core Collection.
- Analysis performed using VOSviewer and CiteSpace software.
Main Results:
- Publication output shows a consistent annual increase, with the United States leading in volume.
- Harvard Medical School and the Journal of Alzheimer's Disease were prominent institutions and journals, respectively.
- Key research terms include neuroinflammation, amyloid-beta, and neurodegeneration, with gut microbiota and mitochondrial dysfunction identified as current hotspots.
Conclusions:
- Emerging research hotspots include NLRP3 inflammasome, TREM2, gut microbiota, mitochondrial dysfunction, and exosomes.
- The interplay between microglia-mediated neuroinflammation and Alzheimer's disease is a central focus and future research trend.
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