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Tissue-specific early and late activated lymphocytes immunophenotype in chronic rhinosinusitis with nasal polyps
Soledad López-Enríquez1,2, Cristina Porras-González1,2, Ramón Moreno-Luna2,3
1Department of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, Virgen Macarena University Hospital, Universidad de Sevilla, Seville, Spain.
Key Points:
T-cell activation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is enriched by late cytotoxic T cells. The proportion of early and intermediate activated cytotoxic T cells decreases in nasal polyps of patients with CRSwNP. Our results identify late activated cytotoxic T cells as potential biomarkers or therapeutic targets for patients with CRSwNP.
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