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Related Experiment Videos

Propafenone ingestion.

T P McHugh, D G Perina

    Annals of Emergency Medicine
    |April 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    A child survived a propafenone overdose, experiencing seizures and cardiac issues. Aggressive life support was crucial for recovery after phenytoin administration.

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    Area of Science:

    • Cardiology
    • Clinical Toxicology
    • Pediatric Emergency Medicine

    Background:

    • Propafenone, a type 1c antiarrhythmic, is now in US clinical trials.
    • Accidental drug ingestion is a significant concern in pediatric populations.

    Observation:

    • A 2-year-old child ingested a large dose of propafenone (1,800 mg or 133 mg/kg).
    • The child developed cardiac conduction abnormalities and generalized seizures post-ingestion.

    Findings:

    • Intravenous phenytoin administration led to cardiopulmonary collapse.
    • Aggressive cardiopulmonary life support was required for patient stabilization.

    Implications:

    • This case highlights the potential severe toxicity of propafenone in children.
    • Prompt and intensive supportive care is vital for managing propafenone overdose in pediatric patients.