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Clostridioides difficile infection across the lifespan: Estimation using life tables
Derek S Brown1, Margaret A Olsen2, Matthew R Keller2
1George Warren Brown School of Social Work, Washington University, St. Louis, Missouri.
Infection Control and Hospital Epidemiology
|January 25, 2024
Summary
The lifetime risk of Clostridioides difficile infection (CDI) is significant, especially for females with Medicaid or end-stage renal disease. Commercially insured males face a lower, but still notable, lifetime risk of this infection.
Area of Science:
- Infectious Diseases
- Epidemiology
- Health Services Research
Background:
- Clostridioides difficile infection (CDI) poses a substantial public health challenge.
- Understanding lifetime risk is crucial for effective prevention and resource allocation.
Purpose of the Study:
- To calculate the lifetime risk of developing Clostridioides difficile infection (CDI) from age 18 onwards.
- To identify specific demographic and insurance groups with elevated lifetime CDI risk.
Main Methods:
- Utilized a life tables approach.
- Analyzed claims data from 2011-2017.
- Calculated lifetime CDI risk rates stratified by sex, insurance type, and medical condition.
Main Results:
- Lifetime CDI risk was 32% for females insured by Medicaid.
- Lifetime CDI risk was 10% for commercially insured males.
- Lifetime CDI risk approached 40% for females with end-stage renal disease.
Conclusions:
- Female patients, particularly those with Medicaid or end-stage renal disease, face a considerably higher lifetime risk of CDI.
- Targeted interventions and surveillance may be warranted for high-risk populations.
- Further research into the underlying factors contributing to these disparities is essential.
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01:22Life Tables
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