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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Related Experiment Video

Updated: Jul 5, 2025

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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Correlation between sarcopenia and cirrhosis: a meta-analysis.

Yifan Cui1, Mingming Zhang1, Jing Guo1

  • 1General Surgery Department, Xuanwu Hospital Capital Medical University, Beijing, China.

Frontiers in Nutrition
|January 25, 2024
PubMed
Summary

Sarcopenia, a condition of muscle loss, affects 41% of cirrhosis patients and significantly increases mortality risk. Early screening and intervention are crucial for improving survival rates in this population.

Keywords:
cirrhosishepatic encephalopathymortalitysarcopeniasurvival rate

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Area of Science:

  • Hepatology and Geriatric Medicine
  • Investigating the complex interplay between liver disease and muscle health.

Background:

  • The relationship between sarcopenia and liver cirrhosis remains incompletely understood.
  • This study aimed to determine the prevalence of sarcopenia in cirrhosis patients and its impact on survival and mortality.
  • Cirrhosis is associated with significant systemic complications, including muscle wasting.

Approach:

  • A systematic review and meta-analysis of 40 studies involving 8,945 patients with liver cirrhosis.
  • Searches were conducted across major databases (PubMed, Web of Science, EMBASE, Cochrane) up to July 2023.
  • Statistical analyses utilized fixed-effects or random-effects models, with publication bias assessed via funnel plots and Egger's test.

Key Points:

  • The overall prevalence of sarcopenia in cirrhosis patients was found to be 41%.
  • Sarcopenia was identified as a significant risk factor for both reduced survival (HR=2.57) and increased mortality (HR=2.13).
  • Higher sarcopenia prevalence was noted in male patients (44%) and those with hepatic encephalopathy (48%), which was also linked to sarcopenia (HR=2.27).

Conclusions:

  • Sarcopenia is highly prevalent in cirrhosis patients and is a significant predictor of adverse outcomes.
  • Routine screening for sarcopenia in individuals with liver cirrhosis is recommended for early detection and management.
  • Interventions targeting sarcopenia may improve survival rates and reduce mortality in the cirrhotic population.