Frequently asked questions about the ISAPP postbiotic definition

Area of Science:

• Microbiology
• Nutrition Science
• Health Sciences

Background:

• The International Scientific Association of Probiotics and Prebiotics (ISAPP) defined postbiotics as inanimate microbial preparations conferring health benefits.
• Concerns and alternative definitions for postbiotics and inactivated microbes have emerged since the ISAPP definition.
• Discussions have occurred in scientific meetings, social media, and personal communications regarding the ISAPP definition.

Purpose of the Study:

• To address questions and concerns raised about the ISAPP definition of postbiotics.
• To clarify the rationale, scope, wording, composition, and commercial implementation of postbiotics.
• To establish expectations for postbiotic safety, efficacy, quantification, and mechanisms of action.

Main Methods:

• Review and discussion of the ISAPP definition of postbiotics.
• Analysis of concerns and alternative perspectives on postbiotic terminology.
• Exploration of key aspects including safety, efficacy, quantification, and mechanisms.

Main Results:

• The paper aims to provide a clearer understanding of the postbiotic definition and its scope.
• It seeks to support a unified comprehension of the postbiotic concept among stakeholders.
• Key areas such as safety, efficacy, and mechanisms are examined to refine the definition.

Conclusions:

• Further clarification of the postbiotic definition is needed to address existing concerns.
• A common understanding of postbiotics is essential for scientific and commercial progress.
• This work contributes to refining the definition and scope of postbiotics for broader acceptance.