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SREBPs as the potential target for solving the polypharmacy dilemma
Xue Wang1, Yanqiu Chen1, Heyu Meng1
1Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute), Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.
Frontiers in Physiology
|January 25, 2024
Summary
Polypharmacy is common in aging populations. Sterol regulatory element binding proteins (SREBPs) are key in metabolic diseases and may offer novel single-drug therapy targets for multiple conditions.
Area of Science:
- Biochemistry
- Molecular Biology
- Metabolic Disease Research
Background:
- Polypharmacy is increasing in aging populations, driven by multiple health conditions and clinical guidelines.
- Metabolic syndrome prevalence is rising globally, posing significant public health and healthcare system challenges.
- Metabolic syndrome increases risks for cardiovascular disease, mortality, and morbidity.
Purpose of the Study:
- To describe the structure, activation, and regulation of Sterol regulatory element binding proteins (SREBPs).
- To explore the role of SREBPs in the modulation of metabolic diseases.
- To identify SREBPs as potential novel therapeutic targets for single-drug treatment of multiple diseases.
Main Methods:
- Review of SREBP structure and function.
- Analysis of SREBP signaling pathways.
- Literature review on SREBP involvement in metabolic diseases.
Main Results:
- SREBPs are basic helix-loop-helix leucine zipper transcription factors regulating lipid biosynthesis and uptake.
- SREBP activation and signaling pathways were elucidated.
- SREBPs are intricately involved in the modulation of metabolic diseases.
Conclusions:
- SREBPs play a crucial role in biological systems regulation, particularly lipid metabolism.
- Dysregulation of SREBPs is linked to metabolic diseases.
- SREBPs represent a promising target for developing single-drug therapies for polypharmacy and metabolic syndrome.
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