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[Considerations on the improvement of height benefit in children with central precocious puberty]

Li-Yang Liang1

  • 1Department of Pediatric Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China (Email: liangliy@mail.sysu.edu. cn).

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|January 25, 2024
PubMed

Insights

Precocious puberty is rising, impacting childhood height. Combining growth hormone with GnRH analogs may improve height outcomes, but optimal timing strategies are needed for better results.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Puberty Disorders

Context:

  • Childhood precocious puberty incidence is increasing due to genetic and environmental factors.
  • Optimizing final height is a primary clinical concern in managing precocious puberty.
  • Current treatments, like gonadotropin-releasing hormone analogs (GnRHa), have variable effects on height improvement.

Purpose:

  • To reevaluate the efficacy of GnRHa monotherapy versus combination therapy with recombinant human growth hormone (rhGH) for height improvement in precocious puberty.
  • To discuss optimal strategies and indications for combination therapy to maximize height benefits.
  • To provide guidance for clinical decision-making in treating precocious puberty.

Summary:

  • GnRHa is the standard treatment for precocious puberty, but height gains can be suboptimal.
  • Combining rhGH with GnRHa is a potential strategy to enhance height outcomes.
  • Evidence-based guidelines are needed to determine the best timing for combination therapy.

Impact:

  • Informing clinical practice for precocious puberty management.
  • Helping children achieve optimal adult height.
  • Improving treatment strategies for growth disorders in pediatric endocrinology.

Keywords:
ChildGonadotropin-releasing hormone analogGrowth hormoneHeight benefitPrecocious puberty

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