Introducing a Comprehensive Score of Systemic Anticancer Treatment Relevance

Area of Science:

• Oncology
• Clinical Pharmacology
• Biomedical Informatics

Background:

• Systemic anticancer therapy (SACT) treatment patterns are complex and varied.
• Existing professional society guidelines are manually curated, laborious, and may not cover all treatment scenarios.
• There is a need for a more comprehensive and quantifiable method to assess SACT relevance.

Purpose of the Study:

• To develop and validate a quantifiable

Main Methods:

• Leveraged a database of 5818 clinical trials and 7012 references from 1943 to the present.
• Calculated a quantifiable

Main Results:

• The relevance score demonstrated a strong association with professional society guideline recommendations in a pilot evaluation.
• The score provided relevance information for thousands of additional therapies not covered by current guidelines.
• The score accurately illustrated trends in SACT adoption over time and by cancer subtype.

Conclusions:

• The developed relevance score offers a comprehensive and quantifiable evaluation of SACT.
• This score can complement existing clinical guidelines and inform treatment decisions.
• The score is anticipated to be valuable for both clinical practitioners and real-world data researchers.