One-Stop Integrated Nanoagent for Bacterial Biofilm Eradication and Wound Disinfection

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Developing effective nano-antibiotics is crucial for wound disinfection to combat drug resistance.
• Existing treatments often lack broad-spectrum efficacy or biocompatibility.
• Novel strategies are needed to enhance antibacterial performance and promote wound healing.

Purpose of the Study:

• To synthesize and evaluate a novel nano-antibiotic, Fe@SAC CQDs/PTA, for wound disinfection.
• To investigate the synergistic antibacterial effects of chemodynamic therapy (CDT) and photothermal therapy (PTT).
• To assess the potential of Fe@SAC CQDs/PTA in inhibiting microbial growth, destroying biofilms, and promoting wound healing.

Main Methods:

• Hydrothermal/ultrasound synthesis of atomically dispersed iron (Fe) on phenolic carbon quantum dots (CQDs) combined with an organic photothermal agent (PTA).
• Evaluation of peroxidase-like activity of Fe@SAC CQDs and photothermal conversion capability of PTA.
• In vitro and in vivo experiments to assess antibacterial efficacy, biofilm inhibition, and wound healing promotion.

Main Results:

• Fe@SAC CQDs/PTA demonstrated excellent eradication of Escherichia coli and Staphylococcus aureus (>99% inactivation efficiency).
• Synergistic chemodynamic therapy (CDT) and photothermal therapy (PTT) were key to the observed antibacterial effects.
• In vitro studies showed inhibition of microbial growth and promotion of bacterial biofilm destruction.
• In vivo experiments indicated significant promotion of wound disinfection and recovery effects.

Conclusions:

• Fe@SAC CQDs/PTA functions as a broad-spectrum antimicrobial nano-antibiotic.
• The synergistic CDT and PTT approach is effective for bacterial biofilm eradication and wound disinfection.
• This nano-antibiotic shows promise for enhancing wound healing and preventing antimicrobial resistance.