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Related Experiment Video

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Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
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Down Syndrome Biobank Consortium: A perspective.

Iban Aldecoa1,2, Isabel Barroeta3, Steven L Carroll4

  • 1Pathology Department, Hospital Clinic de Barcelona-University of Barcelona, Barcelona, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|January 25, 2024
PubMed
Summary
This summary is machine-generated.

Individuals with Down syndrome (DS) face a higher risk of early Alzheimer's disease (AD). The Down Syndrome Biobank Consortium (DSBC) was established to collect and share DS brain tissue for vital research into DS-AD neurobiology.

Keywords:
Alzheimer's diseaseDown syndromebiobankingbrain bankingrepositoryresearch

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Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Background:

  • Individuals with Down syndrome (DS) have trisomy 21, increasing their risk for early-onset Alzheimer's disease (AD).
  • DS represents the largest genetic cohort for AD, yet research is limited by a lack of accessible, well-characterized brain tissue.
  • Current AD clinical trials often exclude individuals with DS, hindering progress in understanding and treating DS-related AD (DS-AD).

Purpose of the Study:

  • To address the knowledge gap in DS-AD neurobiology.
  • To establish an international consortium for collecting and disseminating DS brain tissue across the lifespan.
  • To describe the harmonized protocols and tissue dissemination goals of the Down Syndrome Biobank Consortium (DSBC).

Main Methods:

  • Formation of an international consortium (DSBC) involving 11 biobanking sites across Europe, India, and the USA.
  • Development and implementation of harmonized protocols for brain tissue collection and characterization.
  • Establishment of tissue dissemination goals to facilitate research access.

Main Results:

  • The DSBC has been successfully established with global participation.
  • Harmonized protocols ensure consistent data and tissue quality across sites.
  • A framework for accessible dissemination of DS brain tissue is in place.

Conclusions:

  • The DSBC is a critical resource for advancing the understanding of DS-AD neurobiological mechanisms.
  • Improved access to DS brain tissue will accelerate research into early-onset dementia in individuals with DS.
  • This initiative aims to bridge the gap in DS-AD research and support the development of targeted therapies.