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Interaction between long noncoding RNA and microRNA in lung inflammatory diseases
Jiaqi Li1, Shengyu Huang1, Liangliang Shi1
1Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Immunity, Inflammation and Disease
|January 25, 2024
Summary
Non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are key regulators in lung inflammatory diseases. Their interactions offer promising therapeutic targets, though challenges in drug development remain.
Area of Science:
- Molecular Biology
- Genetics
- Immunology
Background:
- Non-coding RNAs (ncRNAs) regulate gene expression without protein synthesis.
- Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are crucial in immune responses and cellular processes.
- ncRNA interactions significantly impact lung inflammatory diseases.
Purpose of the Study:
- To review the role of ncRNAs, particularly lncRNA-miRNA interactions, in lung diseases.
- To explore disease mechanisms and potential therapeutic strategies involving ncRNAs.
- To provide insights into acute and chronic lung inflammatory diseases and lung cancer.
Main Methods:
- Comprehensive literature review of recent studies.
- Searched electronic databases: PubMed, Web of Science, Scopus.
- Focused on lncRNA and miRNA roles in lung inflammatory diseases.
Main Results:
- Detailed explanation of miRNA and lncRNA characteristics and functions.
- Summary of potential interaction mechanisms between lncRNAs and miRNAs.
- Overview of recent findings on lncRNA-miRNA interactions in lung inflammation.
Conclusions:
- lncRNAs and miRNAs are involved in all stages of lung inflammatory diseases.
- ncRNA-based therapies show promise but face challenges in clinical application.
- Development of stable and effective ncRNA drugs is an ongoing area of research.
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