Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological pump regulation of antibiotic bioaccumulation in size-fractionated planktonic food webs.

Journal of hazardous materials·2026
Same author

Adaptive shifts in amygdala-hippocampal theta coupling govern aversive learning and extinction.

Nature communications·2026
Same author

Dual-target gene therapy in Parkinson's disease: a multicenter phase 1 trial.

Nature medicine·2026
Same author

Fifteen years of intrathecal baclofen therapy in China: complications, safety governance, and a multimodal neuromodulation strategy.

Acta neurochirurgica·2026
Same author

Deep Brain Stimulation of the Posterior Subthalamic Area and the Subthalamic Nucleus in Tremor-Dominant Parkinson's Disease: A Randomized, Crossover Trial.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Effect of high, low, and asymmetric frequency stimulation of the subthalamic nucleus in Parkinson's disease.

Brain stimulation·2026

Related Experiment Video

Updated: Jul 5, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.0K

Optimizing Deep Brain Stimulation in Essential Tremor: A Randomized Controlled Trial for Target Consideration.

Xiaoyu Sun1, Ruinan Shen1, Zhengyu Lin2

  • 1Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neurosurgery
|January 25, 2024
PubMed
Summary

Deep brain stimulation (DBS) targeting the posterior subthalamic area (PSA) shows comparable tremor suppression to the ventral intermediate nucleus (VIM) for essential tremor (ET). PSA-DBS offers superior quality of life improvements and reduced side effects compared to VIM-DBS.

More Related Videos

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
06:32

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

1.3K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.5K

Related Experiment Videos

Last Updated: Jul 5, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.0K
Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
06:32

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring

Published on: July 14, 2023

1.3K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.5K

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Devices

Background:

  • The ventral intermediate nucleus (VIM) is a standard deep brain stimulation (DBS) target for essential tremor (ET).
  • Emerging evidence suggests the posterior subthalamic area (PSA) may offer superior outcomes, but high-level data are limited.

Purpose of the Study:

  • To compare the intraindividual efficacy and side effect profiles of PSA DBS versus VIM DBS in patients with essential tremor.
  • To evaluate tremor reduction, quality of life, and adverse events between the two stimulation targets.

Main Methods:

  • A randomized, double-blind, crossover trial involving bilateral DBS lead implantation targeting both VIM and PSA.
  • Patients were assigned to sequential VIM and PSA stimulation periods post-surgery.
  • The primary endpoint was the change in the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS) total score.

Main Results:

  • No significant difference in overall tremor reduction between PSA DBS and VIM DBS (P = .328).
  • PSA DBS achieved clinical benefit at significantly lower stimulation intensities.
  • PSA DBS demonstrated superior improvement in head tremor (P = .020) and quality of life (P = .046), with fewer speech and gait disturbances.

Conclusions:

  • Posterior subthalamic area DBS is comparable to VIM DBS for tremor suppression in essential tremor.
  • PSA DBS offers advantages in improving disease-specific quality of life and potentially reducing head tremor.
  • PSA DBS may be a more effective target with a better side effect profile for essential tremor management.