Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

2.0K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
2.0K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

3.3K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.3K
Erythropoiesis01:14

Erythropoiesis

4.2K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
4.2K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

940
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
940
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

1.9K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
1.9K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

2.7K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision Transfusion Medicine in the Omics Era.

Blood·2026
Same author

Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism.

bioRxiv : the preprint server for biology·2026
Same author

Resolution of inflammation increases erythropoiesis.

Blood. Red cells & iron·2026
Same author

FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia.

Leukemia·2026
Same author

Exposure to perfluorooctanoic acid accelerates <i>Drosophila melanogaster</i> juvenile development and disrupts mitochondrial metabolism.

bioRxiv : the preprint server for biology·2026
Same author

Blood Cells Far from Equilibrium: Redox Adaptation in Health and Disease.

Antioxidants (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

484

Erythrocyte metabolism.

Panagiotis N Chatzinikolaou1, Nikos V Margaritelis1, Vassilis Paschalis2

  • 1Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece.

Acta Physiologica (Oxford, England)
|January 25, 2024
PubMed
Summary
This summary is machine-generated.

Erythrocyte metabolism is complex, with glycolysis, pentose phosphate pathway, and redox metabolism forming its core. Red blood cells sense oxygen and stress, regulating their function to optimize oxygen delivery.

Keywords:
2,3-BPGfree radicalshaemoglobinmathematical modellingred blood cell

More Related Videos

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
10:17

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

Published on: September 24, 2021

2.7K
Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry
09:16

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry

Published on: February 3, 2023

2.5K

Related Experiment Videos

Last Updated: Jul 5, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

484
Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
10:17

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

Published on: September 24, 2021

2.7K
Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry
09:16

Real-Time Analysis of Bioenergetics in Primary Human Retinal Pigment Epithelial Cells Using High-Resolution Respirometry

Published on: February 3, 2023

2.5K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Hematology

Background:

  • Erythrocytes (red blood cells) possess a unique and complex metabolic network essential for their primary function.
  • Understanding erythrocyte metabolism is crucial for comprehending oxygen transport and related pathologies.

Purpose of the Study:

  • To provide an updated, comprehensive overview of erythrocyte metabolic pathways.
  • To integrate biochemical pathways into a functional metabolic map and analyze metabolic dynamics.

Main Methods:

  • Manual curation and integration of biochemical pathways into a functional map.
  • Synthesis of experimental and computational data to analyze metabolic dynamics.
  • Focus on key pathways including glycolysis, pentose phosphate pathway, and redox metabolism.

Main Results:

  • Established glycolysis, pentose phosphate pathway, and redox metabolism as foundational erythrocyte metabolic processes.
  • Detailed the integration of various pathways including purine/nucleoside metabolism, membrane transport, and emerging pathways.
  • Demonstrated erythrocyte's ability to sense oxygen levels and oxidative stress, adapting its function accordingly.

Conclusions:

  • Erythrocyte metabolism is a finely-tuned system critical for oxygen loading, transport, and delivery.
  • The interplay of core metabolic pathways and adaptive responses to environmental cues dictates erythrocyte function.
  • This review highlights the intricate metabolic machinery enabling efficient oxygen homeostasis.