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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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RAS Mutations Predict Recurrence-Free Survival and Recurrence Patterns in Colon Cancer: A Unicenter Study in Morocco.

Fatima El Agy1, Sanae El Bardai2, Sara Boukansa1

  • 1Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Cancer Control : Journal of the Moffitt Cancer Center
|January 25, 2024
PubMed
Summary
This summary is machine-generated.

Molecular alterations, particularly KRAS mutations, significantly impact colorectal cancer recurrence timing and patterns. KRAS codon 12 mutations are the strongest predictors of recurrence-free survival in colon cancer patients.

Keywords:
RAS mutationscolon cancerrecurrencethe microsatellite instability status

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Limited research exists on molecular alterations influencing cancer recurrence.
  • Understanding these factors is crucial for predicting outcomes in colorectal cancer (CRC).

Purpose of the Study:

  • To investigate the impact of molecular alterations on the timing and site of recurrence in stage I-IV CRC patients.
  • To identify risk factors for recurrence-free survival in colon cancer.

Main Methods:

  • Retrospective analysis of 270 CRC patients.
  • Assessment of full RAS and MSI status.
  • Correlation of molecular alterations with recurrence patterns and survival using Kaplan-Meier and log-rank tests.

Main Results:

  • 85 (31%) patients recurred; 53% had mutant RAS, 48% KRAS mutations.
  • Early recurrence linked to older age, poor differentiation, lymph node positivity, and KRAS mutations (especially p. G12V).
  • RAS mutations, KRAS mutations, and rare mutations were more frequent in lung recurrences. Full RAS status, KRAS codon 13 mutations, differentiation, and perineural invasion independently predicted recurrence-free survival.

Conclusions:

  • Molecular profiles, especially KRAS mutations, are associated with CRC recurrence timing and patterns.
  • KRAS codon 12 mutations are the worst predictors of recurrence-free survival across all stages.