Related Experiment Video

Updated: Jul 5, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

363

TP53 to mediate immune escape in tumor microenvironment: an overview of the research progress

Kai-Li Zhu1, Fei Su1,2, Jing-Ru Yang1,2

  • 1The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.

Molecular Biology Reports
|January 25, 2024
PubMed

Insights

The TP53 gene, encoding the p53 protein, plays a crucial role in cancer development and immune escape. Understanding mutant p53

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • The TP53 gene is a critical tumor suppressor, with its protein product, p53, regulating cell homeostasis and genomic stability.
  • Mutant p53 (Mut p53) actively promotes tumor development by influencing the tumor microenvironment (TME).
  • TP53 mutations are increasingly recognized for their role in mediating tumor immune escape.

Purpose of the Study:

  • To review the multifaceted relationship between the TP53 gene and various tumor types.
  • To elucidate the mechanisms by which Mut p53 drives tumor immune escape.
  • To summarize current advancements in p53-targeted cancer immunotherapy.

Main Methods:

  • Literature review and synthesis of existing research on TP53 gene function in cancer.
  • Analysis of molecular pathways linking mutant p53 to the tumor microenvironment.
  • Compilation of data on immunotherapeutic strategies targeting p53.

Main Results:

  • TP53 mutations are implicated in promoting tumor initiation, progression, and immune evasion.
  • Mutant p53 actively remodels the TME to facilitate tumor growth and suppress anti-tumor immunity.
  • Emerging immunotherapies aim to restore p53 function or target p53-driven pathways.

Conclusions:

  • The TP53 gene and its mutant forms are central to cancer progression and immune escape.
  • Targeting mutant p53 offers a promising avenue for novel cancer immunotherapies.
  • Further research into p53-based therapeutic strategies is warranted.
Keywords:
Immune escapeImmunotherapyTP53Tumors

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