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Key processes in tumor metastasis and therapeutic strategies with nanocarriers: a review
Hongjie Li1, Haiqin Huang2, Haining Tan3
1School of Clinical Medicine, Weifang Medical University, 261053, Weifang, China.
Abstract:
Cancer metastasis is the leading cause of cancer-related death. Metastasis occurs at all stages of tumor development, with unexplored changes occurring at the primary site and distant colonization sites. The growing understanding of the metastatic process of tumor cells has contributed to the emergence of better treatment options and strategies. This review summarizes a range of features related to tumor cell metastasis and nanobased drug delivery systems for inhibiting tumor metastasis. The mechanisms of tumor metastasis in the ideal order of metastatic progression were summarized. We focus on the prominent role of nanocarriers in the treatment of tumor metastasis, summarizing the latest applications of nanocarriers in combination with drugs to target important components and processes of tumor metastasis and providing ideas for more effective nanodrug delivery systems.
Insights
This review explores cancer metastasis, a major cause of cancer death, and nanobased drug delivery systems for inhibiting it. Nanocarriers show promise in targeting metastasis mechanisms for improved cancer treatment strategies.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Cancer metastasis is the primary driver of cancer-related mortality.
- Metastasis involves complex changes at primary and secondary tumor sites throughout disease progression.
- Understanding tumor cell metastasis is crucial for developing advanced therapeutic strategies.
Purpose of the Study:
- To review key features of tumor cell metastasis.
- To summarize nanobased drug delivery systems for inhibiting metastasis.
- To highlight the role of nanocarriers in targeting metastatic processes.
Main Methods:
- Literature review of tumor metastasis mechanisms.
- Analysis of nanocarrier applications in metastasis treatment.
- Synthesis of current research on nanodrug delivery for cancer metastasis.
Main Results:
- Metastatic progression mechanisms were outlined in a sequential order.
- Nanocarriers demonstrate significant potential in targeting critical metastatic components.
- Combined nanodrug strategies offer novel approaches to combat tumor spread.
Conclusions:
- Nanobased drug delivery systems are pivotal in developing novel anti-metastasis therapies.
- Targeting specific metastatic pathways with nanocarriers can enhance treatment efficacy.
- Further research into nanodrug delivery systems can lead to more effective cancer metastasis inhibition.
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