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A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants

Mari Johnson1,2, Irina Chelysheva1,2, Deniz Öner3

  • 1Oxford Vaccine Group, Department of Paediatrics, University of Oxford.

The Journal of Infectious Diseases
|January 25, 2024
PubMed

Insights

Genetic factors may influence respiratory syncytial virus (RSV) severity in infants. This genome-wide study identified candidate genes, like RAB27A, linked to severe RSV infections, offering insights for future research.

Area of Science:

  • Genetics
  • Infectious Diseases
  • Pediatrics

Background:

  • Respiratory syncytial virus (RSV) is a major global cause of infant illness and death.
  • While most children get RSV, genetic factors influencing disease severity are not fully understood.

Purpose of the Study:

  • To investigate genetic risk factors associated with severe RSV infections in infants.
  • To conduct a genome-wide association study (GWAS) to identify genetic variations linked to RSV severity.

Main Methods:

  • Assessed RSV severity using the ReSVinet scale in 251 infants (1 week to 1 year old).
  • Collected genotyping data from European sites (RESCEU Consortium).
  • Employed linear regression to analyze genotype impact on RSV severity and gene expression (microarray).

Main Results:

  • No single nucleotide polymorphisms (SNPs) met genome-wide significance (P < 5 × 10-8).
  • Identified 816 candidate SNPs (P < 1 × 10-4), highlighting genes like LSP1 and RAB27A involved in neutrophil trafficking and cytoskeletal functions.
  • SNPs in the RAB27A locus significantly altered gene expression (FDR P < .05).

Conclusions:

  • Findings suggest potential genetic mechanisms underlying severe RSV infection.
  • Provides biologically relevant information for future research into RSV pathogenesis.
Abstract

Keywords:
GWASRSVeQTLinfectioninflammation

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