Exploring the relation between Interleukin-6 and high-sensitive cardiac troponin T in asymptomatic hemodialysis
Leen Ibrahim1, Katreen Yasin1, Leen Abbas1
1Faculty of Medicine and Health Science, Department of Medicine, An-Najah National University, Nablus, Palestine.
Insights
Inflammation marker interleukin-6 (IL-6) is significantly correlated with high-sensitive cardiac troponin T (h-cTnT) in hemodialysis patients. This finding suggests inflammation contributes to myocardial damage and cardiovascular risk in this population.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- High-sensitive cardiac troponin T (h-cTnT) indicates myocardial damage and is linked to adverse outcomes in asymptomatic hemodialysis patients.
- Inflammation, marked by interleukin-6 (IL-6), is implicated in cardiovascular disease.
- The relationship between IL-6 and h-cTnT in hemodialysis patients requires further investigation.
Purpose of the Study:
- To explore the correlation between IL-6 and h-cTnT in asymptomatic hemodialysis patients.
- To understand the role of inflammation in elevated h-cTnT levels and cardiovascular risk.
Main Methods:
- A cross-sectional study of 81 asymptomatic hemodialysis patients.
- Collection of clinical data and blood samples for IL-6 and h-cTnT measurement.
- Statistical analyses including correlation tests and linear regression.
Main Results:
- A significant positive correlation was found between IL-6 and h-cTnT levels (rho = 0.463, P<0.001).
- h-cTnT levels correlated positively with age and negatively with albumin and transferrin saturation.
- IL-6 levels correlated with age, albumin, iron, and transferrin saturation. Higher h-cTnT was associated with diabetes, hypertension, CAD, CVA, older age, and male gender.
Conclusions:
- A significant association exists between IL-6 and h-cTnT in hemodialysis patients.
- Inflammation likely plays a key role in elevating h-cTnT levels.
- This association may aid in predicting cardiovascular events and guiding interventions to reduce cardiovascular morbidity and mortality.
Background:
High-sensitive cardiac troponin T (h-cTnT), which serves as a marker for myocardial damage, has also been linked to adverse outcomes in asymptomatic hemodialysis patients. This study aims to explore the correlation between interleukin-6 (IL-6) and h-cTnT in asymptomatic hemodialysis patients to unravel the relationship between inflammation and cardiovascular risk.
Methods:
A cross-sectional study involving 81 patients was conducted from November 2022 to March 2023 at An-Najah National University Hospital in Palestine. We gathered clinical data, including comorbidities, and obtained blood samples for measuring IL-6 and h-cTnT levels. We performed statistical analyses, including correlation tests and linear regression, to assess the associations between these variables.
Results:
The study revealed a notable increase in both h-cTnT and IL-6 levels, and a significant correlation between the two (rho = 0.463, P<0.001) in asymptomatic hemodialysis patients. Likewise, h-cTnT levels displayed positive correlations with age (rho = 0.519, P<0.001) and negative correlations with albumin (rho = -0.297, p = 0.007) and transferrin saturation (rho = -0.227, P = 0.042). IL-6 levels exhibited correlations with age (rho = 0.422, P<0.001), albumin (rho = -0.389, P<0.001), iron (rho = -0.382, P<0.001), and transferrin saturation (rho = -0.362, P = 0.001). Notably, higher h-cTnT levels were associated with diabetes, hypertension, a history of coronary artery disease, cerebrovascular accidents, older age, and male gender.
Conclusion:
This study underscores the significant association between the inflammatory marker IL-6 and h-cTnT in asymptomatic hemodialysis patients, suggesting that inflammation may play an essential role in the elevation of h-cTnT levels. This association may have implications for predicting cardiovascular events and guiding interventions to reduce cardiovascular disease morbidity and mortality in hemodialysis patients.
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