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Finite Element Modelling of a Cellular Electric Microenvironment
Published on: May 18, 2021
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Multiphysics simulation of magnetoelectric micro core-shells for wireless cellular stimulation therapy via magnetic
Ram Prasadh Narayanan1, Ali Khaleghi1,2, Mladen Veletić1,2
1Institute of Electronic Systems, Norwegian University of Science and Technology, Trondheim, Norway.
Plos One
|January 25, 2024
Summary
This study introduces a novel magnetoelectric (ME) microdevice for wireless cellular stimulation. This battery-free, electronics-free device enables precise, remote control of electrical stimulation for therapeutic applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Neuroscience
Background:
- Traditional cellular stimulation methods face limitations like invasiveness and complexity.
- Existing techniques often require implanted electronics or complex magnetic induction setups.
- There is a need for wireless, precise, and minimally invasive stimulation technologies.
Purpose of the Study:
- To design and computationally validate a novel magnetoelectric (ME) microdevice for wireless cellular stimulation therapy.
- To demonstrate a battery-free, electronics-free approach for targeted electrical stimulation.
- To explore the potential of ME materials for advanced medical devices.
Main Methods:
- Integration of core-shell magnetoelectric materials with remote coils for magnetic temporal interference (MTI) signal application.
- Utilizing the nonlinear properties of the magnetostrictive core to demodulate high-frequency electromagnetic fields.
- Computational simulations to analyze magnetoelectric coupling factor and device performance at resonance frequencies.
Main Results:
- Achieved a high magnetoelectric coupling factor of 550 V/m·Oe, attributed to mechanical resonance modes.
- Demonstrated localized, tunable, and manipulatable electric potential generation on the piezoelectric shell.
- Validated the concept through rigorous computational simulations, confirming efficient signal transduction.
Conclusions:
- The engineered ME core-shell microdevice is a promising candidate for wireless, high-resolution cellular stimulation therapy.
- This technology offers a minimally invasive alternative for applications in neuroscience, medical devices, and regenerative medicine.
- The findings pave the way for injectable material structures for effective cellular stimulation.
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