Related Experiment Videos
Three days cefoxitin in perforated appendicitis
Abstract:
This study was undertaken to assess the efficacy and safety of a 3-day course of treatment with Mefoxitin (cefoxitin sodium, MSD) in patients with perforated or ruptured appendicitis. A series of 235 patients undergoing surgery for perforated or ruptured appendicitis were treated with cefoxitin for 3 days. Twenty-four patients (10%) developed wound infection and 28 (12%) developed an intra-abdominal abscess postoperatively. No side effects were observed during the study. Compared with the results of our previous series, where a 5-day course of cefoxitin was used, the incidence of wound infection was similar. However the incidence of intra-abdominal abscesses in the present series was significantly higher (p less than 0.01). The results seem to indicate that a 3-day course of cefoxitin is as effective as a 5-day course in controlling the incidence of wound infection following surgery for perforated or ruptured appendicitis, whereas the 3-day course seems to be inferior to a 5-day course in controlling the incidence of intra-abdominal abscesses.
Insights
A 3-day cefoxitin treatment for perforated appendicitis showed similar wound infection rates but higher intra-abdominal abscess rates compared to a 5-day course.
Area of Science:
- Surgical Infectious Diseases
- Antibiotic Therapy Efficacy
Background:
- Perforated or ruptured appendicitis necessitates prompt surgical intervention and antibiotic prophylaxis.
- Optimizing antibiotic duration is crucial for balancing efficacy and minimizing complications.
Purpose of the Study:
- To evaluate the effectiveness and safety of a 3-day cefoxitin regimen in patients with perforated or ruptured appendicitis.
- To compare outcomes of a 3-day cefoxitin course with historical data using a 5-day course.
Main Methods:
- A prospective study involving 235 patients with perforated or ruptured appendicitis.
- Patients received a 3-day course of cefoxitin sodium post-surgery.
- Outcomes including wound infection and intra-abdominal abscess rates were recorded.
Main Results:
- A 10% incidence of wound infection and a 12% incidence of intra-abdominal abscesses were observed.
- Wound infection rates were comparable to a previous 5-day cefoxitin treatment series.
- Intra-abdominal abscess rates were significantly higher (p < 0.01) with the 3-day regimen.
Conclusions:
- A 3-day cefoxitin course appears sufficient for controlling wound infections in perforated appendicitis surgery.
- However, a 3-day regimen may be less effective than a 5-day course in preventing intra-abdominal abscesses.