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Three days cefoxitin in perforated appendicitis.

G Lose, B Holm, T Bauer

    Annales Chirurgiae Et Gynaecologiae
    |January 1, 1986
    PubMed
    Summary
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    A 3-day cefoxitin treatment for perforated appendicitis showed similar wound infection rates but higher intra-abdominal abscess rates compared to a 5-day course.

    Area of Science:

    • Surgical Infectious Diseases
    • Antibiotic Therapy Efficacy

    Background:

    • Perforated or ruptured appendicitis necessitates prompt surgical intervention and antibiotic prophylaxis.
    • Optimizing antibiotic duration is crucial for balancing efficacy and minimizing complications.

    Purpose of the Study:

    • To evaluate the effectiveness and safety of a 3-day cefoxitin regimen in patients with perforated or ruptured appendicitis.
    • To compare outcomes of a 3-day cefoxitin course with historical data using a 5-day course.

    Main Methods:

    • A prospective study involving 235 patients with perforated or ruptured appendicitis.
    • Patients received a 3-day course of cefoxitin sodium post-surgery.
    • Outcomes including wound infection and intra-abdominal abscess rates were recorded.

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    Main Results:

    • A 10% incidence of wound infection and a 12% incidence of intra-abdominal abscesses were observed.
    • Wound infection rates were comparable to a previous 5-day cefoxitin treatment series.
    • Intra-abdominal abscess rates were significantly higher (p < 0.01) with the 3-day regimen.

    Conclusions:

    • A 3-day cefoxitin course appears sufficient for controlling wound infections in perforated appendicitis surgery.
    • However, a 3-day regimen may be less effective than a 5-day course in preventing intra-abdominal abscesses.