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Related Experiment Video

Updated: Jul 5, 2025

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Rothia in Nonsmall Cell Lung Cancer is Associated With Worse Survival.

Yamato J Takabe1, Emily Allen2, Lyla Allen2

  • 1Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Nichols High School, Buffalo, New York; Yale University, New Haven, Connecticut.

The Journal of Surgical Research
|January 25, 2024
PubMed
Summary

The bacterium Rothia was found in Nonsmall Cell Lung Cancer (NSCLC) patients. While Rothia presence correlated with worse survival, it also indicated less tumor proliferation and a more favorable immune microenvironment.

Keywords:
BioinformaticsMicrobiomeNonsmall cell lung cancerRothiaSurvival analysis

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Area of Science:

  • Oncology
  • Microbiome Research
  • Cancer Genomics

Background:

  • The microbiome significantly influences cancer biology.
  • Limited research exists on the microbiome's impact on Nonsmall Cell Lung Cancer (NSCLC) patient outcomes.
  • Hypothesis: Specific microorganisms correlate with NSCLC patient survival.

Purpose of the Study:

  • To investigate the relationship between specific microorganisms and NSCLC patient survival.
  • To identify microbial signatures associated with different survival rates in NSCLC.

Main Methods:

  • Analysis of 647 NSCLC patients from The Cancer Genome Atlas (TCGA).
  • Utilized R software for data analysis.
  • Employed Volcano Plot analysis to compare microbial abundance between short and long survivors.

Main Results:

  • Rothia was abundant in short-term survivors; Blastococcus, Leptospira, and Haematobacter were found in long-term survivors.
  • Rothia presence alone was linked to overall survival.
  • Rothia-positive NSCLC showed reduced cell proliferation, less fraction altered, homologous recombination deficiency, and increased stromal cell infiltration.
  • Rothia-positive tumors exhibited higher infiltration of CD8 T cells, CD4 T cells, Monocytes, and NK cells, alongside a robust interferon-gamma response and T-cell receptor richness.

Conclusions:

  • NSCLC with Rothia is associated with poorer survival but also favorable oncological characteristics.
  • Rothia presence correlates with decreased cell proliferation and an improved tumor immune microenvironment.
  • The association of Rothia with mortality in NSCLC may be independent of its oncological characteristics.