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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities

Shimeng Wang1, Hexing Sun1, Guanyuan Chen1

  • 1Department of Thyroid and Breast Surgery, Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), 57 Changping Road, Shantou 515041, China.

Critical Reviews in Oncology/Hematology
|January 25, 2024
PubMed

Insights

RNA-binding proteins (RBPs) regulate gene expression post-transcriptionally. This review highlights RBPs

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • RNA-binding proteins (RBPs) control gene expression through post-transcriptional mechanisms like splicing and translation.
  • Aberrant RBP activity is implicated in various diseases, notably cancer, by affecting tumor cell characteristics.
  • Understanding RBP roles is crucial for developing targeted breast cancer therapies.

Purpose of the Study:

  • To review the regulatory mechanisms and signaling crosstalk of RBPs in breast cancer.
  • To identify RBPs with prognostic potential based on their impact on cancer cell behavior.
  • To provide an overview of current and emerging RBP-targeted therapeutic strategies for breast cancer.

Main Methods:

  • Literature review synthesizing current research on RBPs in breast cancer.
  • Analysis of RBP functions related to proliferation, invasion, apoptosis, and therapy resistance.
  • Compilation of data on RBP-based prognostic factors and therapeutic targets.

Main Results:

  • RBPs significantly influence breast cancer cell proliferation, invasion, apoptosis, and resistance to therapy.
  • Specific RBPs demonstrate potential as prognostic biomarkers in breast cancer.
  • Targeting RBPs offers promising avenues for novel breast cancer treatment strategies.

Conclusions:

  • RBPs are critical regulators in breast cancer, impacting tumor progression and treatment response.
  • Further research into RBP mechanisms can uncover new prognostic markers and therapeutic targets.
  • Targeting RBPs represents a promising frontier in personalized breast cancer therapy.
Keywords:
Breast cancerRNARNA-binding proteinTherapeutic targets

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